2003; 73(26) : 3427 as a potential anti-inflammatory and antithrombotic agent. The selected patients were 45 - 60 years old (the mean age was 52.0 Â± 4.8 years) with moderate to severe knee pain (VAS â¥ 4) visited in a rheumatology clinic in Sari, Iran as outpatients. Giannini EH, In group treated with 300 mg kg1 extract, one rat died in day 4 due to peritonitis. The results of this study suggest that combination of E. angustifolia and ginger extracts are safe and may have some efficacy in patients with knee OA. , [PubMed], Zitzer SF, Dawson JO. Ther Adv Musculoskelet Dis. Since the extract â¦ Supplementation with an extract of Elaeagnus angustifolia, a shrub related to buckthorn, improves womenâs sexual function. 2012; 4(3) : 181 The aim of this study is the evaluation of the effect of Afghan senjed (Elaeagnus Angustifolia L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. The ginger herb is extensively used in the tropical areas and E. angustifolia was suggested to have had analgesic and anti-inflammatory effects . (2011) have investigated effect of different doses of E. angustifolia water extract with and without morphine on analgesic ratio in rats. In traditional medicine, fruits and flowers of E. angustifolia are used as an aphrodisiac and anti-fever medicine. Abstract: Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Development of criteria for the classification and reporting of osteoarthritis. Statistics: statistical analysis was done by the SPSS-12 using Ï2 test, Independent t-test and Wilcoxon Signed-rank test for comparisons of mean values of patients at baseline and after the intervention. Our patients had a moderate to severe pain and not reducing analgesic consumption may be because of severity of pain before the intervention. 1998; 41(5) : 778 Asieh Ghobadifar A, Ebrahimzadeh We suggest further studies with different doses and durations of intervention of combined E. angustifolia and ginger extract. The absorbance of mixture was measured at 760 nm after 2 hours of incubation at room temperature. 2003; 11(11) : 783 The mean of BMI was 30.0 Â± 4.5 kg/m2. The dried extracts were powdered and mixed with starch powder and then were encapsulated. Int J Evid Based Healthc. In rats of positive control group, 3 rats were died in 9, 10 and 11 days post induction of ulcerative colitis. Final formulations for clinical trial were controlled microbiologically. Life Sci. In folk medicines, Elaeagnus angustifolia (Elaeagnaceae) is a Mediterranean medicine representative of the family Elaeagnaceae, commonly named oleaster, which is cultivated in north American, Eurasia â¦ ; 17(11):e2200. Colon, rat received 10% extract gel via enema, minimal to moderate healing of ulcerative colitis associated with infiltration of inflammatory cells in the mucosa are seen (H and E stain, ×200), Colon, rat received 20% extract gel via enema, moderate healing of colonic ulcer as regeneration of mucosal epithelium, infiltration of mononuclear inflammatory cells in the lamia propria between crypts are observed (H and E stain, ×200), https://scialert.net/abstract/?doi=jpt.2015.29.35, Colon, rat of positive control group, chronic ulcerative colitis as fibrosis of the mucosa, cystic dilation of crypts and infiltration of inflammatory cells in the mucosa and submucosa are observed (H and E stain, ×80). Fruit in the Muséum de Toulouse Elaeagnus angustifolia, commonly called Russian olive, silver berry, oleaster, or wild olive, is a species of Elaeagnus, native to western and central Asia, Iran, from â¦ 2001; 72(3) : 255 -49 Patients were excluded if they were pregnant or lactating, if their disorder was secondary to inflammatory arthritis, or with uncontrolled hypertension (blood pressure Ë 140/90), heart failure (class 3 or 4), renal failure (serum creatinine Ë 1.5), liver dysfunction (liver enzyme Ë 1.5 times more than normal), raised ESR (according age and sex), history of peptic disease or bronchospasm, and cerebral vascular accident or myocardial infarction in past year. There is some evidence about nutraceuticals in the management of OA but there is not sufficient reliable evidence regarding safety or effectiveness [2-8]. The therapeutic methods for UC are on basis of anti-inflammatory agents, glucocorticoids and salicylates as well as biological agents Against Tumor Necrosis Factor-α (TNF-α). The results showed edible extract 600 mg had the best effect on healing process. [DOI][PubMed], Chrubasik JE, Roufogalis BD, Chrubasik S. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. In folk medicines, Elaeagnus angustifolia(Elaeagnaceae) is a Mediterranean medicine representative of the family Elaeagnaceae, commonly named oleaster, which is cultivated in north American, Eurasia â¦ A randomized, double-blind, placebo-controlled trial study studied the effects of ginger in the treatment of knee OA in 261 patients. Vaezi et al. Elaeagnus angustifolia (Russian olive, Russian silverberry, Oleander) is one of the herbs applied mostly in Irans traditional medicine (Farahbakhsh et al., 2011). Helmick CG, J Ethnopharmacol. However, a more secure and easier way is needed for treatment and prevention of this disease that minimizes the expenses and the side effects of the medical methods (Shepherd, 1991; Fiocchi, 1998). Elaeagnus angustifolia contains vitamins A, B and K as well as valuable compounds including olein, styrene, lanolin, 8% oil, sugar, organic acids, flavonoids and tannin. Dietary supplements for osteoarthritis. Deyo RA, The pain reduced significantly but analgesic consumption did not change. Zahedan Journal of Research in Medical Sciences, The Official Journal of Zahedan University of Medical Sciences. Felson DT, In 3 rats, hyperemia and linear healing of ulcers were seen in the colon. In the present study, 70 Sprague dawley rats were randomly divided into seven equal groups including negative control, positive control, enamel gel 10 and 20%, edible extract 300 and 600 mg and also pure base gel enema groups. Brandt K, Osteoarthritis (OA) is the most common rheumatic disorder with increasing prevalence with advancing age . For example, Medhi et al. Ibfelt HH, The primary endpoint of the study was pain on standing after 6 weeks. The classic criteria method for OA of the knee is based upon the presence of knee pain plus at least 3 of the following 6 clinical characteristics: greater than 50 years of age, morning stiffness for less than 30 minutes, crepitus on active motion of the knee, bony tenderness, bony enlargement and no palpable warmth . This plant can tolerate and survive a wide variety â¦ , The absorbance of the reaction mixture was measured at 415. Based on histopathological examination and determination of the ulcer index (Gurbuz et al., 2003) found potent gastroprotective effect for the methanolic fruit extract of E. angustifolia in ethanol induced gastric ulcer in rats. (2012) have studied the effect of E. angustifolia fruit on experimental cutaneous wound healing in rats, that their results demonstrate aqueous extract of E. angustifolia accelerates cutaneous wound healing. showed significant improvement in symptoms for both groups before crossover; however, at the studyâs end there was no difference between ginger and placebo . 2007; 12(1) : 49 This is a study for evaluation of the efficacy and safety of Elaeagnus angustifolia and ginger extracts in patients with osteoarthritis of the knee. During the study, there were some subtle but not biochemical side effects and there was not any difference between the drug and the placebo. Results of this study showed extract of Elaeagnus angustifolia can be used for improvement of healing process in colon ulcers and edible extract 600 mg has the best effect in comparison to edible 300 mg and 20% enema gel extracts. M, Mobini Natanzi et al. Starch powder was used as placebo. 2 Elaeagnus angustifolia is one of traditional herbal medicines widely used for treatment of digestive diseases. Healing Effects of Elaeagnus angustifolia Extract in Experimentally Induced Ulcerative Colitis in Rats: A. Khodakarm-Tafti, D. Mehrabani, L. Homafar and G. Farjanikish: Abstract: Ulcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease that involves mostly the mucosa of the colon and increases the possibility of colon cancer.Elaeagnus angustifolia â¦ fects of Elaeagnus angustifolia flower extract and sildenafil citrate on female orgasmic dis-order in women in 2013. is one in the family of riparian trees growing near the rivers or water corridors. Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. On basis of the results, both forms of E. angustifolia extract have positive effects on healing process of this disorder. Total phenol values are expressed in terms of gallic acid equivalent (GAE), mg/g of extract), which is a common reference compound. Osteoarthritis (OA) is the most common joint disorder without any curative treatment so, pharmacologic and nonpharmacologic modalities are used to improve pain and disability. To compare at baseline values, the patients in drug group had more improvement in pain intensity according to VAS (P = 0.02) and the physician evaluation according to a 4- scale scoring (P = 0.03). Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. Conclusions: Copyright Â© 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. In our subjects, two thirds of the patients were regular analgesic users. Arthritis Rheum. Recently, it is shown aqueous extract of E. angustifolia L. leaf has obvious protective effects on myocardial/reperfussion injury which may be related to the improvement of myocardial oxidative stress states (Wang et al., 2014). Drugs Aging. -207 About 51 g extract was obtained from 100 g of the milled powder of the plant via hydroalcohol method. Injections in joints were not allowed during the study. Ulcerative colitis was induced by 3% acetic acid (3 mg kg1 stat1) enema in all rats except negative control group. The present The present study evaluated the impact of two doses of EA extract compared with ibuprofen â¦ Rabiei Briefly, 0.5 mL solution of extract in methanol was mixed with 1.5 m: of methanol, 0.1 mL of 10% aluminum chloride, 0.1 mL of 1 m potassium acetate, and 2.8 mL of distilled water and left at room temperature for 30 minutes. The patients received ginger extract or placebo twice daily, with acetaminophen allowed as rescue medication. Of all 97.5% of patients were females and the mean of BMI was 30 Â± 4.5 kg/m2. The patients in both groups had experienced some side effects. , Objectives: Based on our findings, the E. angustifolia fruit extract â¦ In 2 cases, degeneration and necrosis of epithelium, dilatation of some crypts and cryptitis were observed (Fig. For standardization, the total phenol and flavonoids of extracts were determined. The study was approved by the Ethics Committee of Mazandaran University of Medical Sciences and was recorded in IRCT (IRCT code: IRCT138812121828N3). Other rats of this group had minor gross changes including focal linear ulcer healing associated with hyperemia and edema of the mucosa. -9 [PubMed], Ramezani M, Hosseinzadeh H, Daneshmand N. Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice. The simple size was estimated according to some similar studies [3, 5, 13]. Standard laboratory chow and tap water were available ad libitum. Histopathological findings in the colon including regeneration and healing of mucosa, erosion and ulceration, cryptitis, cystic dilatation of the crypts and aggregation of inflammatory cells were compared in all control and experimental groups. Grossly, multifocal to diffuse ulcers were seen in the colon so that in two rats peritonitis with inflammation of serosal surface of colon was determined. Before the intervention, knee radiography, serum creatinine, liver enzymes, ESR, blood pressure were done. In placebo group, 4 participants had dyspepsia, 1 headache, 1 oral ulcer, 1 itching, 1 raised blood pressure and 1 palpitation. Bmi was 30.0 Â± 4.5 kg/m2 100 mg/mL in methanol were females and the mean of BMI was Â±... 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